Protection against phishing, malware, and other threats targeting email and collaboration tools in Microsoft 365
To exclude any potential issues on the frontend, try performing the action via a different browser and preferably, in a private session. If you are still facing the same issue, you can try making the changes via PowerShell instead. The set of *-AntiPhishPolicy and *-AntiPhishRule cmdlets are responsible for managing anti=phishing policies, for the exact syntax needed consult the documentation, or capture the network output when performing the change in the portal.
And if you are facing issues with PowerShell also, best open a support case.